In recent years it has been discovered that many changes occur in CLL affecting the transcriptional regulation of many proteins involved in the malignancy. These include epigenetic changes such as gain or loss of methylation on DNA promoters, mirRNA expression, aberrant transcription factors and other nuclear factors. Understanding of the transcriptional regulation of CLL pathogenesis will provide insight on how to cut-off CLL’s oncogene addiction.
Raval A, Tanner SM, Byrd JC, Angerman EB, Perko JD, Chen SS, Hackanson B, Grever MR, Lucas DM, Matkovic JJ, Lin TS, Kipps TJ, Murray F, Weisenburger D, Sanger W, Lynch J, Watson P, Jansen M, Yoshinaga Y, Rosenquist R, de Jong PJ, Coggill P, Beck S, Lynch H, de la Chapelle A, Plass C. Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia. Cell. 2007; 129(5):879-90
Chen S-S, Raval A, Johnson AJ, Hertlein E, Liu T-H, Jin VX, Sherman MH, Liu S, Dawson DW, Williams KE, Lanasa M, Liyanarachchi S, Lin TS, Marcucci G, Pekarsky Y, Davuluri R, Croce CM, Guttridge DC, Teitell MA, Byrd JC, and Plass C. (2009) “Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia.” PNAS. 106(32):13433-8